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Cardiotoxicity Ligand Set
基本信息
NACRES | NA.77 |
General description【一般描述】 | A set of 52 compounds are arranged in 96-well format, one compound per well (250 μl at 10 mM in DMSO) |
Application【应用】 | Cardiotoxicity Ligand Set has been used in the cumulative drug dosage studies on engineered human induced pluripotent stem cell-derived cardiomyocyte (hiPS-CM) tissues. |
Biochem/physiol Actions【生化/生理作用】 | Cardiotoxicity is an important cause for concern in drug development and appears to cut across therapeutic indications and drug classes. Several drugs have been removed from the market recently because of prolonging the QT interval or causing Torsades de Pointes (TdP). The Cardiotoxicity Ligand Set features a wide variety of drugs including anti-arrhythmics, antihistamines, antibiotics, anticonvulsants, antidepressants and antipsychotics that are known to have cardiotoxic side-effects. |
Features and Benefits【特点和优势】 | This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. SDFile provided to construct a database containing:
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产品性质
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
安全信息
Pictograms【象形图】 | GHS07,GHS08,GHS09 |
Signal word【警示用语:】 | Danger |
Hazard Statements | H302 - H350 - H360FD - H362 - H411 |
Precautionary Statements | P202 - P263 - P264 - P273 - P301 + P312 - P308 + P313 |
Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 1A - Lact. - Repr. 1B |
Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
WGK | WGK 3 |