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Cardiotrophin-1 from mouse
产品编号: | 3423421 |
规格: | recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture |
包装规格: | 10 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Cardiotrophin-1 from mouse
CT-1
基本信息
NACRES | NA.32 |
General description【一般描述】 | Cardiotrophin-1 is from interleukin (IL)-6 family of cytokines. It is mainly present in adipose tissues, osteoclasts and cardiomyocytes. Cardiotrophin-1 works through gp130 (glycoprotein) and the LIFR (LIF receptor). |
Biochem/physiol Actions【生化/生理作用】 | In adipocytes, cardiotrophin-1 helps in activating signaling pathways associated with metabolism. It controls energy homeostasis, and glucose and lipid metabolism. High levels of cardiotrophin-1 are reported in obesity and metabolic syndrome. Absence of cardiotrophin-1 in mice causes mature-onset obesity, insulin resistance and hypercholesterolemia. In osteoclasts, it enhances osteoblast activity as well as mineralization. It also participates in cardiomyocyte survival, hypertrophy, cardiac fibroblast proliferation and collagen type I synthesis. Cardiotrophin-1 is associated with arterial fibrosis and stiffness. |
Sequence【序列】 | SQREGSLEDH QTDSSISFLP HLEAKIRQTH NLARLLTKYA EQLLEEYVQQ QGEPFGLPGF SPPRLPLAGL SGPAPSHAGL PVSERLRQDA AALSVLPALL DAVRRRQAEL NPRAPRLLRS LEDAARQVRA LGAAVETVLA ALGAAARGPG PEPVTVATLF TANSTAGIFS AKVLGFHVCG LYGEWVSRTE GDLGQLVPGG VA |
Physical form【外形】 | Lyophilized from 0.5mg/ml in 5mM Tris, pH 8.0. |
Reconstitution【重悬】 | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1- 1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃. |
产品性质
biological source【生物来源】 | mouse |
recombinant【重组】 | expressed in E. coli |
Assay【测定】 | ≥98% (HPLC) ≥98% (SDS-PAGE) |
form【形式】 | lyophilized |
potency【效能】 | ≤1.0 ng/mL ED50 |
mol wt【分子量】 | 21.3 kDa |
packaging【包装】 | pkg of 10 μg |
technique(s) | cell culture | mammalian: suitable |
impurities【杂质】 | <0.1 EU/μg endotoxin, tested |
color【颜色】 | off-white to yellow |
UniProt accession no.【UniProt登记号】 | Q60753 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | mouse ... CTF1(13019) |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |