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卡莫氟

Carmofur
产品编号:3423488
规格:≥98% (HPLC), powder
CAS NO:61422-45-5
包装规格:10 MG,50 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
342348810 MG1230
342348850 MG3630
产品别名

61422-45-5

卡莫氟

Carmofur

1-Hexylcarbamoyl-5-fluorouracil

HCFU

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C11H16FN3O3
Molecular weight
257.26
MDL number
MFCD00866284
PubChem Substance ID【PubChem化学物质编号】
329774890
NACRES
NA.77
Application【应用】
Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .
Biochem/physiol Actions【生化/生理作用】
Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.
Carmofur acts as an inhibitor of fatty acid amide hydrolase (FAAH), N-acylethanolamine acid amidase (NAAA) and acid ceramidase (ASAH1). Carmofur has a therapeutic activity against colorectal and cervical cancer. It can inhibit the severe acute respiratory syndrome (SARS)-CoV-2 main protease (Mpro) in vitro.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
color【颜色】
white to off-white
solubility【溶解性】
DMSO: >15 mg/mL
storage temp.【储存温度】
2-8℃
SMILES string
CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O
InChI
1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
InChI key
AOCCBINRVIKJHY-UHFFFAOYSA-N
packaging【包装】
10, 50 mg in glass bottle
安全信息
Pictograms【象形图】
GHS06,GHS08
Signal word【警示用语:】
Danger
Hazard Statements
H301 - H361
Precautionary Statements
P201 - P301 + P310 + P330
Hazard Classifications【危险分类】
Acute Tox. 3 Oral - Repr. 2
Storage Class Code【储存分类代码】
6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
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