您的位置：首页 > 产品中心 > 87958-67-6， CGP 52608
CGP 52608
产品别名
87958-67-6
CGP 52608
1-[3-Allyl-4-oxo-thiazolidine-2-ylidene]-4-methyl-thiosemicarbazone
N-Methyl-2-[4-oxo-3-(2-propen-1-yl)-2-thiazolidinylidene]-hydrazinecarbothioamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C8H12N4OS2 |
| Molecular weight | 244.34 |
| MDL number | MFCD00942304 |
| PubChem Substance ID【PubChem化学物质编号】 | 329775098 |
| NACRES | NA.77 |
| Application【应用】 | CGP 52608 has been used as a RAR related orphan receptor α (RORα) synthetic agonist in THP-1 macrophages, in human monocyte cells THP1 and somatic testicular cells. |
| Biochem/physiol Actions【生化/生理作用】 | CGP 52608 is a thiazolidine derivative and an antiarthritic compound. It possesses immunostimulatory functionality and elicits antiproliferative effect in colon tumors. It is cytotoxic towards neural cell lines. CGP 52608 induces apoptosis in tumor and also favors G0-G1 cell cycle phase accumulation in neural cell lines. CGP 52608 is a specific activator of retinoic acid receptor-related orphan receptor α (RORA). |
| Features and Benefits【特点和优势】 | This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% |
| form【形式】 | solid |
| solubility【溶解性】 | DMSO: >30 mg/mL H2O: insoluble |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | CNC(=S)N\N=C1/SCC(=O)N1CC=C |
| InChI | 1S/C8H12N4OS2/c1-3-4-12-6(13)5-15-8(12)11-10-7(14)9-2/h3H,1,4-5H2,2H3,(H2,9,10,14)/b11-8- |
| InChI key | DDYJDIHOSRTMSE-FLIBITNWSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
