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CHIC-35
| 产品编号： | 3424770 |
| 规格： | ≥97% (chiral, HPLC) |
| CAS NO： | 848193-72-6 |
| 包装规格： | 1 MG，5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3424770 | 1 MG | 1920 | |||
| 3424770 | 5 MG | 6860 |
产品别名
848193-72-6
CHIC-35
(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide
Compound (S)-35
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H15ClN2O |
| Molecular weight | 262.73 |
| MDL number | MFCD11045286 |
| PubChem Substance ID【PubChem化学物质编号】 | 329775186 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging. |
| Features and Benefits【特点和优势】 | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (chiral, HPLC) |
| form【形式】 | solid |
| solubility【溶解性】 | DMSO: >10 mg/mL H2O: <2 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1 |
| InChI | 1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1 |
| InChI key | ABIVOOWWGYJNLV-JTQLQIEISA-N |
| packaging【包装】 | 1, 5 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
