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卡纽替尼二盐酸盐

CI-1033
产品编号:3425875
规格:≥98% (HPLC)
CAS NO:289499-45-2
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
34258755 MG941
342587525 MG3290
产品别名

289499-45-2

卡纽替尼二盐酸盐

CI-1033

N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride

PD183805

N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride

Canertinib dihydrochloride

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C24H25ClFN5O3· 2HCl
Molecular weight
558.86
MDL number
MFCD09954112
PubChem Substance ID【PubChem化学物质编号】
329775143
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
CI-1033 is a potent, irreversible ATP binding site–directed pan-ErbB tyrosine kinase inhibitor with IC50 in the low nanomolar range for EGFR, HER2, and ErbB-4.
Features and Benefits【特点和优势】
This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
solid
solubility【溶解性】
DMSO: >10 mg/mL
H2O: >10 mg/mL
storage temp.【储存温度】
−20℃
SMILES string
Cl.Cl.Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
InChI
1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16;;/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29);2*1H
InChI key
JZZFDCXSFTVOJY-UHFFFAOYSA-N
Gene Information
human ... EGFR(1956), ERBB2(2064), ERBB4(2066)
packaging【包装】
5, 25 mg in glass bottle
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H315 - H319 - H335
Precautionary Statements
P261 - P305 + P351 + P338
Hazard Classifications【危险分类】
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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