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Cibenzoline 琥珀酸盐
Cibenzoline succinate
| 产品编号： | 3425887 |
| 规格： | ≥98% (HPLC), solid |
| CAS NO： | 100678-32-8 |
| 包装规格： | 10 MG，50 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
100678-32-8
Cibenzoline 琥珀酸盐
Cibenzoline succinate
Exacor
2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate
Cibenol
Cipralan
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H18N2 ·C4H6O4 |
| Molecular weight | 380.44 |
| MDL number | MFCD00941423 |
| PubChem Substance ID【PubChem化学物质编号】 | 24892426 |
| NACRES | NA.77 |
| General description【一般描述】 | Cibenzoline also called (±)-2-(2,2-diphenylcyclopropyl)-2-imidazoline succinate, is generally used in stereo combination of R(+) and S(−) forms. It also exhibits anticholinergic activity.. Cibenzoline is known to improve left ventricular diastolic dysfunction by reducing left ventricular pressure gradient. |
| Biochem/physiol Actions【生化/生理作用】 | Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells. |
| Features and Benefits【特点和优势】 | This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to brown |
| solubility【溶解性】 | H2O: ≥5 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC(=O)CCC(O)=O.C1CN=C(N1)C2CC2(c3ccccc3)c4ccccc4 |
| InChI | 1S/C18H18N2.C4H6O4/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17;5-3(6)1-2-4(7)8/h1-10,16H,11-13H2,(H,19,20);1-2H2,(H,5,6)(H,7,8) |
| InChI key | XFUIOIWYMHEPIE-UHFFFAOYSA-N |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P264 - P270 - P301 + P312 - P501 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
