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Clarithromycin, Ready Made Solution

产品编号:3426544
规格:50 mg/mL in DMSO
CAS NO:81103-11-9
包装规格:2 ML
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
34265442 ML2540
产品别名

81103-11-9

Clarithromycin, Ready Made Solution

6-O-methyl erythromycin

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C38H69NO13
Molecular weight
747.95
MDL number
MFCD00865140
PubChem Substance ID【PubChem化学物质编号】
329824644
NACRES
NA.85
General description【一般描述】
Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions.
Application【应用】
Clarithromycin may be used for-
  • the study of the effects of clarithromycin on rate-dependent changes in QT, Tp-e and proarrhythmic events performed on arterially perfused rabbit left ventricular wedge preparations
  • the culture of parasites expressing GFP (green fluorescence protein) targeted to the apicoplast, to be further used for microscopy-based assays
  • the study of the synergism of NAB741 with clarithromycin in microtiter plates.
Biochem/physiol Actions【生化/生理作用】
Macrolides, such as clarithromycin, prevent protein synthesis in bacteria, by binding to 50S ribosomal subunit. It also binds to other ribosomal proteins, and prevents the translocation of pepti-dyl-tRNA. In patients with refractory asthma, it is capable of regulating the levels of interleukin-8 (IL-8), and neutrophil accumulation and activation in lungs. Thus, it might be used as an additional therapy in asthma to reduce noneosinophilic airway inflammation.
Other Notes【其他说明】
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids
产品性质
Quality Level【质量水平】
200
description【描述】
Ready Made Solution
form【形式】
liquid
storage condition【储存条件】
dry media (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.)
concentration【浓度】
50 mg/mL in DMSO
color【颜色】
colorless to faint yellow
Mode of action【作用机制】
protein synthesis | interferes
antibiotic activity spectrum【抗生素抗菌谱】
Gram-positive bacteria
storage temp.【储存温度】
−20℃
InChI
1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
InChI key
AGOYDEPGAOXOCK-KCBOHYOISA-N
packaging【包装】
2ML
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)【闪点(F)】
188.6 °F
Flash Point(C)【闪点(C)】
87 ℃
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