(R)-(-)-丙炔苯丙胺 盐酸盐

(R)-(-)-Deprenyl hydrochloride provides neuroprotection which may be relevant to Parkinson?’s disease, Alzheimer?’s disease, Huntington?’s disease, and stroke. It is an inhibitor of MAO-B (monoamine oxidase-B) which demonstrates extensive neuroprotective effects shown to be uncorrelated with MAO-B inhibiting activity. It demonstrates protection of dopaminergic neurons from excitotoxicity mediated by NMDA activation. It also demonstrates decreases in apoptosis of PC12 neuronal cells accompanied with an induction of new protein synthesis through direct transcriptional and translational interaction, and reduced cell death and internucleosomal DNA degredation at concentrations too low to inhibit MAO-B.

Stable under recommended storage conditions. Incompatible with oxidizing agents.

MFCD00069299

C₁₃H₁₇N?HCl

223.74

Ambient temperatures.

Crystalline Powder

Soluble in water at 100mM

14,8428

36/38
Irritating to eyes and skin.

26-37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste

DA0292500

否

 

H315-H319
Causes skin irritation.Causes serious eye irritation.

P280a-P264-P305+P351+P338-P321-P332+P313-P337+P313
Wear protective gloves and eye/face protection.Wash thoroughly after handling.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Specific treatment (see label).If skin irritation occurs: Get medical advice/attention.If eye irritation persists: Get medical advice/attention.