uPA 抑制剂 II

A cell-permeable oxazolidinone-carboxamidine compound that acts as a potent, selective, and active-site targeting inhibitor of urokinase-type plasminogen activatoruPA Inhibitor II, UK122 acts as a potent, selective and active-site targeting urokinase-type plasminogen activator (uPA) inhibitor. However, its activity against trypsin, thrombin, tPA, and plasmin is greatly reduced. It is also effectively inhibits the migration (80% inhibition) and invasion (68% inhibition) of uPA-expressing CFPAC-1 pancreatic cells, without affecting its proliferation.

Store in a cool place. Incompatible with oxidizing agents,.

C₁₇H₁₃N₃O₂.CF₃CO₂H

405.30

Keep Cold. Light Sensitive.

Solid

Soluble in dimethyl sulfoxide.

否