LY 303511-CAS 154447-38-8-Calbiochem

C₁₉H₁₈N₂O₂

306.36

A cell-permeable, negative control for the phosphatidylinositol-3-kinase (PI-3 kinase) inhibitor, LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not affect PI-3 kinase activity even at concentrations ≥100 µM.
A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not inhibit PI 3-kinase even at a concentration of 100 µM. Shown to bind to the same site as I-BET (Cat. no. 401010) and reversibly inhibit BET bromodomain proteins BRD2, BRD3 & BRD4 (IC₅₀ ~10 µM).

Cell permeable: yes
Target IC₅₀: Does not inhibit PI 3-kinase even at a concentration of 100 µM
Product does not compete with ATP.
Reversible: no
Primary Target
Negative control for the PI 3-kinase inhibitor LY 294002

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Dittman, et al. 2014. ACS Chem Biol.9, 495.
Ding, J., et al. 1995. J. Biol. Chem.270, 11684.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze

amber

DMSO: 100 mg/mL

ambient

−20℃

1S/C19H18N2O2/c22-17-13-18(21-11-9-20-10-12-21)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13,20H,9-12H2

NGAGMBNBKCDCDJ-UHFFFAOYSA-N

1 mg in Plastic ampoule

11 - Combustible Solids

WGK 1