Cathepsin L Inhibitor IV-Calbiochem

C₂₇H₂₉N₃O₄S

491.60

A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC₅₀ = 1.9 nM). Inhibits the release of Ca²⁺ and hydroxyproline from bone in a bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).
A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC₅₀ = 1.9 nM). Also inhibits the release of Ca²⁺ and hydroxyproline from bone in an in vitro bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).

Cell permeable: yes
Target IC₅₀: 1.9 nM against Cathepsin L
Product does not compete with ATP.
Primary Target
cathepsin L
Reversible: yes

Toxicity: Standard Handling (A)

1-Naphthalenesulfonyl-Ile-Trp-CHO

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Yasuma, T., et al. 1998. J. Med. Chem. 41, 4301.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze

white to off-white

DMSO: 5 mg/mL

ambient

−20℃

1 mg in Plastic ampoule

11 - Combustible Solids

WGK 1