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EST-CAS 88321-09-9-Calbiochem
| 产品编号： | 4061673 |
| 规格： | A cell-permeable, irreversible inhibitor of cysteine proteases. |
| CAS NO： | 88321-09-9 |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4061673 | 1 MG | 2570 |
产品别名
88321-09-9
EST-CAS 88321-09-9-Calbiochem
Loxistatin, (2S,3S)- trans-Epoxysuccinyl-L-leucylamido-3-methylbutane Ethyl Ester, E-64d
Loxistatin, (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane Ethyl Ester, E-64d
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H30N2O5 |
| Molecular weight | 342.43 |
| MDL number | MFCD00132883 |
| General description【一般描述】 | A cell-permeable, irreversible inhibitor of cysteine proteases. Similar to E-64 (Cat. No. 324890) but devoid of charged groups. Reported to inhibit calpain-1 activation. The inhibitory activity of EST has been attributed to E-64c, the free acid formed by hydrolysis of the ester in vivo. Used in animal models of muscular dystrophy. A cell-permeable, irreversible inhibitor of cysteine proteases. Similar to E-64 (Cat. No. 324890) but is devoid of charged groups. The inhibitory activity of EST has been attributed to E-64c, the free acid formed by hydrolysis of the ester in vivo. Used in animal models of muscular dystrophy. Recommended working concentration is 10-100 µM. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Target IC50: 10-100 µM for calpain-1 Product does not compete with ATP. Reversible: no Primary Target calpain-1 |
| Warning【警告】 | Toxicity: Irritant (B) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C. |
| Other Notes【其他说明】 | Inomata, M., et al. 1996. Arch. Biochem. Biophys. 328, 129. Mehdi, S. 1991. Trends Biochem. Sci. 16, 150. McGowan, E.B., et al. 1989. Biochem. Biophys. Res. Commun.158, 432. Tamai, M., et al. 1987. J. Pharmacobiodyn.10, 678. Komatsu, K., et al. 1986. Exp. Neurol. 91, 23. Tamai, M., et al. 1986. J. Pharmacobiodyn. 9, 672. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: soluble |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1 |
| InChI key | SRVFFFJZQVENJC-IHRRRGAJSA-N |
| packaging【包装】 | 1 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
