FPT Inhibitor II-Calbiochem

C₁₇H₂₈NO₅P · 2Na

403.36

A highly selective and potent inhibitor of Ras farnesyltransferase (IC₅₀ = 75 nM). Inhibits geranylgeranyltransferase I (IC₅₀ = 24 µM) and II (IC₅₀ = 24 µM) at much higher concentrations. Also inhibits Ras farnesylation in whole cells by ~90% at 10-100 µg/ml (25-250 µM). Resistant to cleavage by phosphorylation.
A cell permeable potent and selective inhibitor of farnesyltransferase (FTase; IC₅₀ = 75 nM). Also inhibits Ras farnesylation in whole cells by ~90% at 25-250 µM. Resistant to cleavage by phosphorylation.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Cell permeable: yes
Target IC₅₀: 75 nM against Ftase
Product does not compete with ATP.
Reversible: no

Toxicity: Standard Handling (A)

Manne, V., et al. 1995. Drug Development Res.34, 121.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

white

water: ≥10 mg/mL

ambient

−20℃

1 mg in Plastic ampoule

11 - Combustible Solids

WGK 1