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Guanosine 3',5'-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt-Calbiochem
| 产品编号： | 4061685 |
| 规格： | A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II. |
| 包装规格： | 1 μMOL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Guanosine 3',5'-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt-Calbiochem
Rp-8- pCPT-cGMPS, TEA, PKG Inhibitor III
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H15ClN5O6PS2 · xC6H15N |
| Molecular weight | 503.88 (free acid basis) |
| General description【一般描述】 | A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II. Significantly more lipophilic and membrane-permeable than Rp-cGMPS or Rp-8-Br-cGMPS (Cat. No. 370674). Note: 1 µmol = 0.61 mg. A potent, cell-permeable inhibitor of protein kinase G Iα, Iβ, and type II. A combination of the protein kinase inhibitor Rp-cGMPS and the widely used cGMP analog, 8-pCPT-cGMP. Significantly more lipophilic and membrane-permeant than Rp-cGMPS and Rp-8-Br-cGMPS. Resistant to hydrolysis by mammalian cyclic nucleotide dependent phosphodiesterases. Note: 1 µmol = 0.61 mg. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target PKG1α Product does not compete with ATP. Reversible: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Abd Alla, S., et al. 1996. Eur. J. Biochem.241, 498. Lee, S.J., et al. 1996. Dev. Biol.180, 324. Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol.60, 94. Willmott, N., et al. 1996. J. Biol. Chem.271, 3699. Butt, E., et al. 1994. Eur. J. Pharmacol. 269, 265. |
| Legal Information【法律信息】 | Sold under license of U.S. Patent 5,625,056, Patents DE 3,802,865.4, and DE 4,217,679 issued to BIOLOG LSI. CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥99% (HPLC) |
| form【形式】 | lyophilized |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| solubility【溶解性】 | water: 0.5 mg/mL DMSO: soluble |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 1 μmol in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
