Guanosine 3',5'-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt-CAS 172806-20-1-Calbiochem

C₁₈H₁₄BrN₅O₆PS · Na

562.27

A metabolically-stable, competitive inhibitor of protein kinase G type Iα and Iβ (K_i = 30 nM) that also blocks cGMP-gated retinal type ion channels (IC₅₀ = 25 µM). Also reported to block the activation of purified PKA type II (K_i = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 5 µmol = 2.81 mg.
A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (K_i = 30 nM). Blocks cGMP-gated retinal type ion channels (IC₅₀ = 25 µM) and the activation of purified PKA type II (K_i = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 1 µmol = 0.56 mg.

Cell permeable: yes
Target K_i: 30 nM against PKG1α & 1β
Product does not compete with ATP.
Reversible: no
Primary Target
PKG1α & 1β

Toxicity: Standard Handling (A)

Wei, J.Y., et al. 1996. Biochemistry35, 16815.
Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

lyophilized

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

water: 5 mg/mL

ambient

−20℃

1 μmol in Plastic ampoule

11 - Combustible Solids

WGK 2