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1-β-D-Arabinofuranosylcytosine-CAS 147-94-4-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4061774 | 1 G | 1540 |
产品别名
147-94-4
1-β-D-Arabinofuranosylcytosine-CAS 147-94-4-Calbiochem
Ara-C, Cytarabine, Cytosine Arabinoside
基本信息
| Empirical Formula【经验(实验)分子式】 | C9H13N3O5 |
| Molecular weight | 243.22 |
| MDL number | MFCD00066487 |
| General description【一般描述】 | Anticancer, antiviral agent that is especially effective against leukemias. Induces apoptosis in human myeloid leukemia cells and in rat sympathetic neurons. Induces G1/S phase cell cycle arrest. Cytosine analog that acts as a potent inhibitor of eukaryotic cellular and viral replicative DNA synthesis. AraCTP, formed by intracellular phosphorylation of AraC, is utilized as a substrate by DNA polymerases, which incorporate AraCMP residues into DNA. Incorporated 3′-terminal AraCMP residues inhibit further DNA synthesis by impeding chain elongation by DNA polymerase. AraC is used clinically in the treatment of various cancers, particularly leukemias and lymphomas. Also used to inhibit proliferation of cultured cells and replication of eukaryotic viruses (e.g. vaccinia virus, herpes simplex virus). Also shown to induce apoptosis in human myeloid leukemia cells and in post-mitotic rat sympathetic neurons. |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target Anticancer, antiviral agent that is especially effective against leukemias Product does not compete with ATP. Reversible: no Cell permeable: no |
| Warning【警告】 | Toxicity: Harmful & Carcinogenic / Teratogenic (E) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C. |
| Other Notes【其他说明】 | Zarilli, R., et al. 1999. Gastroenterology 116, 1358. Dessi, F., et al. 1995. J. Neurochem.64, 1980. Grant, S., et al. 1994. Oncol. Res. 6, 87. Greenberg, A.L., et al. 1994. Cancer74, 1261. Perrino, F.W., et al. 1997. J. Biol. Chem.269, 16357. Tomkins, C.E., et al. 1994. J. Cell Sci.107, 1499. Taddie, J.A., and Traktman, P. 1993. J. Virol.67, 4323. Brach, M.A., et al. 1992. Mol. Pharmacol.41, 60. Este, E., et al. 1992. Blood79, 2246. Owens, J.K., et al. 1992. Cancer Res.52, 2389. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| color【颜色】 | white |
| solubility【溶解性】 | water: 1 mM |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1 |
| InChI key | UHDGCWIWMRVCDJ-CCXZUQQUSA-N |
| packaging【包装】 | 1 g in Plastic ampoule |
安全信息
| Pictograms【象形图】 | GHS07,GHS08 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H317 - H361fd |
| Precautionary Statements | P201 - P202 - P261 - P280 - P302 + P352 - P308 + P313 |
| Hazard Classifications【危险分类】 | Repr. 2 - Skin Sens. 1 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
