Calpastatin, Human, Recombinant, Domain I-Calbiochem

100

lyophilized solid

Calbiochem^®

OK to freeze

white

aqueous buffer: 1 mg/mL
water: 1 mg/mL

wet ice

−20℃

1 mg in Glass bottle

An endogenous protease inhibitor that acts specifically on Calpain I (Cat. No. 208712), a Ca²⁺-dependent cysteine protease. Widely distributed in mammalian and avian cells. Has better inhibitory action than Calpain Inhibitor I (Cat. No. 208719) and Calpain Inhibitor II (Cat. No. 208721). Calpastatin corresponds to domain I of human calpastatin. The inhibitory sequence of human domain I consists of at least 18 amino acid residues.
Domain I of human calpastatin. Endogenous protease inhibitor that acts specifically on Calpain-1 (Cat. No. 208712). Exhibits greater inhibitory potency than calpain inhibitors I and II.

Product does not compete with ATP.
Primary Target
calpain-1
50 nM completely inhibits the activity of 7.5 µg/ml calpain I
Reversible: no
Cell permeable: no

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

homogeneous by SDS-PAGE

Salamino, F., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1326.
Uemori, T., et al. 1990. Biochem. Biophys. Res. Commun. 166, 1485.
Asada, K., et al. 1989. J. Enzyme Inhib.3, 49.

Not available for sale in Japan.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

11 - Combustible Solids

WGK 1