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FTase Inhibitor I-Calbiochem
| 产品编号： | 4061832 |
| 规格： | The FTase Inhibitor I controls the biological activity of FTase. This small molecule/inhibitor is primarily used for Cancer applications. |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
FTase Inhibitor I-Calbiochem
N-[2(S)-[2(R)-Amino-3-mercaptopropylamino]-3-methylbutyl]-Phe-Met-OH, B581
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H38N4O3S2 |
| Molecular weight | 470.69 |
| General description【一般描述】 | A potent, cell-permeable inhibitor of farnesyltransferase (FTase) that is about 37-fold more active against FTase (IC50 = 21 nM in vitro) than against geranylgeranyltransferase (GGTase; IC50 = 790 nM). Very resistant to proteolysis. A potent, cell-permeable, selective, peptidomimetic inhibitor of farnesyltransferase (FTase) that is approximately 37-fold more active against FTase (IC50 = 21 nM in vitro) than against geranylgeranyltransferase (GGTase; IC50 = 790 nM). Very resistant to proteolysis. |
| Biochem/physiol Actions【生化/生理作用】 | Target IC50: 21 nM against FTase in vitro Product does not compete with ATP. Primary Target FTase Cell permeable: yes Reversible: no |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Physical form【外形】 | Supplied as a trifluoroacetate salt. |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Yamaguchi, M., et al. 2004. Stroke35, 1750. Cox, A.D., et al. 1994. J. Biol. Chem.269, 19203. Garcia, A.M., et al. 1993. J. Biol. Chem. 268, 18415. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥90% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) |
| color【颜色】 | white |
| solubility【溶解性】 | water: 1 mg/mL DMSO: 5 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 1 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
