γ-Secretase Inhibitor II-Calbiochem

C₃₃H₅₇F₂N₅O₉

705.83

A cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase (IC₅₀ = 13 µM for Aβ). Displays only weak inhibitory activity against calpain II (IC₅₀ = 100 µM in a purified enzyme assay).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
A cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase with an IC₅₀ of 13 µM for the inhibition of amyloid β-protein (Aβ) production in β-amyloid precursor protein (APP)-transfected Chinese hamster ovary cells. Displays only weak inhibitory activity against calpain II (IC₅₀ = 100 µM in a purified enzyme assay).

Cell permeable: yes
Primary Target
γ-secretase
Product does not compete with ATP.
Target IC₅₀: 13 µM against γ-secretase
Reversible: yes

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Wolfe, M.S., et al. 1999. Biochemistry38, 4720.
Wolfe, M.S., et al. 1998. J. Med. Chem. 41, 6.
Citron, M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 13170.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze

white

DMSO: 10 mM

ambient

−20℃

1 mg in Plastic ampoule

11 - Combustible Solids

WGK 1