您的位置:首页 > 产品中心 > InSolution Caspase-3 Inhibitor I, Cell-Permeable-Calbiochem
InSolution Caspase-3 Inhibitor I, Cell-Permeable-Calbiochem
产品编号: | 4061853 |
规格: | The InSolution |
包装规格: | 1 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
InSolution Caspase-3 Inhibitor I, Cell-Permeable-Calbiochem
Cell-permeable, DEVD-CHO; CPP32/Apopain Inhibitor, Cell-permeable
基本信息
Empirical Formula【经验(实验)分子式】 | C94H158N20O27 |
Molecular weight | 2000.38 |
General description【一般描述】 | A cell-permeable inhibitor of caspase-3. The C-terminal DEVD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-3 (Ki<1 nM) that has also been shown to strongly inhibit PARP cleavage in cultured human osteosarcoma cell extracts (IC50 = 200 pM). The N-terminal sequence (residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide. |
Biochem/physiol Actions【生化/生理作用】 | Primary Target caspase-3 Target IC50: 200 pM inhibiting PARP cleavage in cultured human osteosarcoma cell extracts Product does not compete with ATP. Reversible: yes Cell permeable: yes |
Warning【警告】 | Toxicity: Irritant (B) |
Sequence【序列】 | Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO |
Physical form【外形】 | A 5 mM (1 mg/100 µl) solution of Caspase-3 Inhibitor I, Cell-permeable (Cat. No. 235423) in DMSO. |
Reconstitution【重悬】 | Following initial thaw, aliquot, purge with inert gas, and freeze (-20°C). |
Other Notes【其他说明】 | Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305. Nicholson, D.W. 1996. Nature Biotechnol. 14, 297. Schlegel, J., et al. 1996. J. Biol. Chem.271, 1841. Lin, Y.-Z., et al. 1995. J. Biol. Chem.270, 14255. Nicholson, D.W., et al. 1995. Nature 376, 37. Tewari, M., et al. 1995. Cell 81, 801. Lazebnik, Y.A., et al. 1994. Nature371, 346. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥90% (HPLC) |
form【形式】 | liquid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
packaging【包装】 | 1 mg in Glass bottle Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 1 |
Flash Point(F)【闪点(F)】 | 188.6 °F - (Dimethylsulfoxide) |
Flash Point(C)【闪点(C)】 | 87 ℃ - (Dimethylsulfoxide) |