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InSolution Gö 6976-CAS 136194-77-9-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4061855 | 1 ML | 3120 |
产品别名
136194-77-9
InSolution Gö 6976-CAS 136194-77-9-Calbiochem
Go 6976, Solution, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole
基本信息
| Empirical Formula【经验(实验)分子式】 | C24H18N4O |
| Molecular weight | 378.43 |
| MDL number | MFCD00236434 |
| General description【一般描述】 | Inhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKCα-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC δ-, ε-, and ζ-isoenzymes even at micromolar levels. A potent antagonist of HIV-1 induction. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product competes with ATP. Target IC50: 7.9 nM, 2.3 nM, and 6.2 nM, for rat brain PKC, Ca2+-dependent PKC α-isozyme, and PKCβI, respectively Reversible: yes Primary Target PKC |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 500 µg/ml solution of Gö 6976 (Cat. No. 365250) in anhydrous DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-20°C). |
| Other Notes【其他说明】 | Gschwendt, M., et al. 1996. FEBS Lett.392, 77. Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun.200, 1536. Martiny-Baron, G., et al. 1993. J. Biol. Chem.268, 9194. Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA90, 674. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| solubility【溶解性】 | DMSO: 5 mg/mL |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29) |
| InChI key | VWVYILCFSYNJHF-UHFFFAOYSA-N |
| packaging【包装】 | 1 ml in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (Dimethylsulfoxide) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (Dimethylsulfoxide) |
