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InSolution Sirtinol-Calbiochem
产品别名
InSolution Sirtinol-Calbiochem
2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H22N2O2 |
| Molecular weight | 394.47 |
| General description【一般描述】 | A cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity. Does not affect human HDAC1. Reported to block Sir2p transcriptional silencing activity in vivo (IC50 = 25 µM) and NAD-dependent HDAC activity in purified recombinant yeast Sir2p and human SIRT2 in vitro (IC50 = 68 µM and 38 µM, respectively). |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target ySir2 Product does not compete with ATP. Reversible: no Target IC50: 48 µM, 131 µM and 58 µM for ySir2, hSIRT1 and hSIRT2, respectively |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 10 mM (1 mg/254 µl) solution of Sirtinol (Cat. No. 566320) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and refrigerate (4°C). |
| Other Notes【其他说明】 | Mai, A., et al. 2005. J. Med. Chem.48, 7789. Grozinger, C.M., et al. 2001. J. Biol. Chem.276, 38837. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 1 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (Dimethylsulfoxide) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (Dimethylsulfoxide) |
