Metastin (45-54)-Calbiochem

C₆₃H₈₃N₁₇O₁₄

1302.44

A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptors). Induces an increase in intracellular Ca²⁺ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (K_i = 42 pM) compared to Metastin (Cat. No. 445885).
A decapeptide with C-terminally amidated LRF-motif that acts as a potent and selective agonist of AXOR12 and hOT7T175 (a novel human G-protein-coupled receptor). More potent than the parent peptide. Induces an increase in intracellular Ca²⁺ levels in CHO/h175 and CHO/AXOR12:Gqi5 cells and exhibits about 8-fold higher receptor binding affinity (K_i = 42 pM, determined by competitive binding analysis) as compared to Metastin (Cat. No. 444885).

Product does not compete with ATP.
Reversible: no
Target K_i: 42 pM for AXOR12 and hOT7T175
Cell permeable: no
Primary Target
AXOR12 and hOT7T175

Toxicity: Standard Handling (A)

H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂

Kotani, M., et al. 2001. J. Biol. Chem.276, 34631.
Ohtaki, T., et al. 2001. Nature411, 613.
Muir, A.I., et al. 2001. J. Biol. Chem.276, 28969.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (HPLC)

lyophilized solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

white

DMSO: 5 mg/mL

ambient

−20℃

1 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1