NanoFabTx^TM PEG-PCL drug formulation screening kit

Drug loading screening kit, for synthesis of PEGylated PCL nanoparticles
Kit components :
PEGPCL-L(915203-500mg)
PEGPCL-H(912549-500mg)
PEGPCL-UH (917788-500mg)
Stabilizer-Nano (907766-5g)

2-8℃

NanoFabTx^™ nanoformulation reagent kits enable users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. NanoFabTx^™ kits provide an easy-to-use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx^™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery.
Protocols for two different particle synthesis methods are included.

• A Nanoprecipitation protocol to prepare drug-encapsulated nanoparticles in standard laboratory glassware.
• A Microfluidics protocol using commercial platforms or syringe pumps.

The microfluidics protocol uses NanoFabTx^™ device kits (911593), which provide all the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

NanoFabTx^™ PEG-PCL drug loading screening kit is a ready-to-use nanoformulation kit for the synthesis of PEGylated PCL nanoparticles. This kit provides properly selected PEGylated PCL polymers, stabilizer and protocolssynthesis by nanoprecipitation and microfluidic methods. Three different PEGylated PCLs are included in this kit, allowing rapid screening of optimal materials for enhancing drug loading.

Poly (ethylene glycol)-block-poly(caprolactone) (PEG-PCL) is a biocompatible and biodegradable polymer that has been approved by the FDA and the EMA for biomedical and pharmaceutical applications. PEG-PCL based nanoparticles have been widely used as drug delivery systems for different types of therapeutic molecules, to achieve controlled drug release.

NANOFABTX is a trademark of sigma-aldrich Co. LLC

10 - Combustible liquids

WGK 3