TNF-α Antagonist-Calbiochem

C₅₈H₇₁N₁₁O₁₅S₂

1226.38

An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC₅₀ = 5 µM) in binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. Exhibits about twofold higher activity than other known WP5 binding site derived mimetics. Designation WP9QY arises from the binding to the WP9 binding site of the TNF-β/TNF-receptor(I) complex as template, and the introduction of amino acids, Gln and Tyr.
An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC₅₀ = 5 µM) in the binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. The designation WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor (I) complex as template, and the introduction of amino acids Glu and Tyr.

Product does not compete with ATP.
Reversible: no
Target IC₅₀: 5 µM as TNF-α antagonist
Cell permeable: no

Toxicity: Standard Handling (A)

H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)

Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.

Sold under license of U.S. Patent 6,265,535.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

lyophilized

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

water: 1 mg/mL
5% acetic acid: 5 mg/mL

ambient

−20℃

1 mg in Plastic ampoule

11 - Combustible Solids

WGK 1