来自肝脏的微粒体，合并

NA.47

Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).

Microsomes from Liver, Pooled has been used in following studies:

• inhibition of microsomal lipid peroxidation.
• hydroxylation of isorhynchophylline (ISOR) in rats.

Microsomes might act as cell organelles and are actively involved in protein synthesis. Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids. Murine liver microsomes plays a crucial role in degradation of small antimicrobial β^2,2-amino acid derivatives.
肝微粒体是来源于肝细胞内质网的亚细胞颗粒。这些微粒体是药物代谢酶(包括细胞色素 P-450)的丰富来源。不同来源的微粒体池有助于研究外源代谢和药物相互作用。

rat (Sprague-Dawley)

200

~10 mg per vial

dry ice

−70℃

10 - Combustible liquids

WGK 3