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氨基蝶呤成品溶液
Aminopterin Ready Made Solution
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4063500 | 1 ML | 4980 |
产品别名
54-62-6
氨基蝶呤成品溶液
Aminopterin Ready Made Solution
4-Aminofolic acid
(S)-2-{4-[(2,4-Diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid
4-Amino-PGA
4-Aminopteroyl-L-glutamic acid
4-氨基-PGA
4-氨基叶酸
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H20N8O5 |
| Molecular weight | 440.41 |
| MDL number | MFCD00036692 |
| Biochem/physiol Actions【生化/生理作用】 | Aminopterin is a synthetic derivative of pterin. It is used as a folic acid antagonist. It competitively inhibits dihydrofolate reductase (DHFR) and blocks tetrahydrofolate synthesis. This inhibition blocks DNA, RNA and protein synthesis. Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase. Aminopterin was first administered for cancer therapy, as a drug targeting metabolism, specifically in pediatric leukemia. Later on it was demonstrated to be more potent yet more toxic than methotrexate. |
产品性质
| Assay【测定】 | ≥85% |
| Quality Level【质量水平】 | 200 |
| form【形式】 | liquid |
| storage condition【储存条件】 | protect from light |
| concentration【浓度】 | 50 mg/mL in DMSO |
| solubility【溶解性】 | DMSO: 50 mg/mL |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | OC(CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=NC3=C(N)N=C(N)N=C3N=C2)C=C1)=O)=O |
| InChI | 1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27) |
| InChI key | TVZGACDUOSZQKY-UHFFFAOYSA-N |
安全信息
| Pictograms【象形图】 | GHS06,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 - H360 |
| Precautionary Statements | P201 - P280 - P301 + P330 + P331 + P310 - P308 + P313 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Oral - Repr. 1B |
| Storage Class Code【储存分类代码】 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
| Flash Point(F)【闪点(F)】 | 188.6 °F |
| Flash Point(C)【闪点(C)】 | 87 ℃ |
