Anti-phospho-p53 (pSer³⁹²) antibody produced in rabbit

MFCD02097164

NA.41

p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.

Does not react with non-phosphorylated p53.

synthetic peptide corresponding to residues around Ser³⁹² of human p53 conjugated to KLH.

Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol

Purified using protein A and peptide affinity chromatography.

rabbit

200

unconjugated

affinity isolated antibody

primary antibodies

polyclonal

buffered aqueous glycerol solution

antigen 53 kDa

mouse, human

microarray: suitable
western blot (chemiluminescent): 1:1,000 using p53 fusion proteins with CKII phosphorylation or an extract of hydroxyurea-treated MvILu cells

P04637

wet ice

−20℃

human ... TP53(7157)
mouse ... Trp53(22059)

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12 - Non Combustible Liquids

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