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Aphidicolin, Ready Made Solution
| 产品编号： | 4063529 |
| 规格： | from Nigrospora sphaerica |
| CAS NO： | 38966-21-1 |
| 包装规格： | 1 ML |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4063529 | 1 ML | 1690 |
产品别名
38966-21-1
Aphidicolin, Ready Made Solution
ICI 69653
NSC-234714
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H34O4 |
| Molecular weight | 338.48 |
| EC number【EC 号】 | 200-664-3 |
| MDL number | MFCD00083214 |
| NACRES | NA.85 |
| General description【一般描述】 | Aphidicolin is a tetracyclic diterpene with antiviral and antimitotic properties used for cell cycle synchronization in various cell lines. |
| Application【应用】 | Aphidicolin, from Nigrospora sphaerica, was used for cell cycle synchronization of tobacco BY-2 cells. It is used to block the entry of cells into S-phase. |
| Biochem/physiol Actions【生化/生理作用】 | Aphidicolin specifically inhibits DNA polymerase α that is responsible for DNA replication. It also inhibits α-like DNA polymerases of plants and yeasts but does not inhibit synthesis of RNA and proteins. Aphidicolin competes for the dCTP-specific binding site on DNA polymerase α specifically. Aphidicolin has antiviral and antimitotic properties. It blocks the cell cycle at S phase. It has been shown to induce apoptosis in HeLa cells. |
| Physical form【外形】 | Aphidicolin Ready Made Solution supplied as a 1 mg/ml solution in DMSO. |
| Other Notes【其他说明】 | Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids |
产品性质
| biological source【生物来源】 | Nigrospora sphaerica |
| Quality Level【质量水平】 | 200 |
| vapor pressure【蒸汽压】 | 0.55 hPa ( 20 ℃) |
| form【形式】 | liquid |
| color【颜色】 | clear colorless |
| solubility【溶解性】 | H2O: miscible (completely) |
| Mode of action【作用机制】 | DNA synthesis | interferes enzyme | inhibits |
| antibiotic activity spectrum【抗生素抗菌谱】 | neoplastics viruses |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1 |
| InChI key | NOFOAYPPHIUXJR-APNQCZIXSA-N |
| packaging【包装】 | 1 ml |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - closed cup |
| Flash Point(C)【闪点(C)】 | 87 ℃ - closed cup |
