MMP-13 Inhibitor-CAS 544678-85-5-Calbiochem

C₂₂H₂₀F₂N₄O₂

410.42

A potent inhibitor of MMP-13 activity (IC₅₀ = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.
A pyrimidine dicarboxamide compound that potently inhibits MMP-13 activity (IC₅₀ = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.

Primary Target
MMP-13 activity
Product does not compete with ATP.
Target IC₅₀: 8 nM against MMP-13
Reversible: no
Cell permeable: no

Toxicity: Standard Handling (A)

Further dilute in buffer immediately prior to use.

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Engel, C.K., et al. 2005. Chem. Biol.12, 181.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

light yellow

DMSO: 10 mg/mL

ambient

2-8℃

1 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 1