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细胞色素P450 人
Cytochrome P450 human
| 产品编号： | 4063747 |
| 规格： | 1A2 Isozyme Microsomes, with P450 Reductase and cytochrome b5, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4) |
| 包装规格： | 1 VIAL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
细胞色素P450 人
Cytochrome P450 human
基本信息
| Enzyme Commission (EC) Number【酶学委员会(EC)编号】 | 1.6.2.4 ( BRENDA | IUBMB ) |
| MDL number | MFCD03456520 |
| NACRES | NA.54 |
| Application【应用】 | Human cytochrome P450 has been used in a study to investigate non-viral environmental risk factors for nasopharyngeal carcinoma. Human cytochrome P450 has also been used in a study to investigate the dynamics and hydration of the active sites of mammalian cytochromes. |
| Biochem/physiol Actions【生化/生理作用】 | Cytochrome P450 enzymes are heme containing monooxygenases which are found primarily in the mammalian liver. They catalyze the oxidative metabolism of xenobiotics. This metabolism is the initial step in the biotransformation and elimination of a wide variety of drugs and environmental pollutants from the body. This product has a molecular mass of approximately 58 kDa. Amiodarone, furafylline, and cimetidine are inhibitors, whereas tobacco, insulin, and omeprazole are inducers of the enzyme. The isozyme CYP1A2 is a major pathway for the 6-hydroxylation of melatonin in vivo. This isozyme also catalyzes the 5-hydroxylation of thiabendazole. 细胞色素 P450 是一个具有异质性的同工酶家族，其主要功能是氧化小分子，既是中间代谢(如脂肪酸)的功能，也是对外源化合物(药物或毒素)解毒的功能。一些亚型具有较窄的底物特异性，而另一些则是替代的。 |
| Other Notes【其他说明】 | Microsomes containing recombinant human CYP1A2, recombinant rabbit NADPH-P450 reductase, and cytochrome b5. |
| Physical form【外形】 | Solution in 100 mM potassium phosphate buffer, pH 7.4. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in baculovirus infected insect cells (BTI-TN-5B1-4) |
| form【形式】 | solution |
| mol wt【分子量】 | 58 kDa |
| packaging【包装】 | vial of 0.5 nmol |
| UniProt accession no.【UniProt登记号】 | P05177 |
| application(s) | cell analysis |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... CYP1A2(1544) |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
