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10Panx1 三氟乙酸盐
10Panx1 trifluoroacetate salt
产品别名
955091-53-9
10Panx1 三氟乙酸盐
10Panx1 trifluoroacetate salt
WRQAAFVDSY trifluoroacetate salt
10Panx trifluoroacetate salt
Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr trifluoroacetate salt
基本信息
| Empirical Formula【经验(实验)分子式】 | C58H79N15O16 · xC2HF3O2 |
| Molecular weight | 1242.34 (free base basis) |
| NACRES | NA.77 |
| Application【应用】 | 10Panx1 trifluoroacetate salt has been used as the selective pannexin-1 mimetic inhibitory peptide to study the involvement of pannexin-1 in praliciguat (PRL) inhibition of the NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome. |
| Biochem/physiol Actions【生化/生理作用】 | The pannexin-1 (panx1) extracellular sequence-derived 10panx1 functions as a reversible panx1 channel blocker (IC50 = 52 μM; human panx1-overexpressing HEK cells) that effectively inhibits ATP-induced dye-uptake in panx1 HEK cells co-expressing rat or human P2X7R (IC50 = 93 μM), as well as in murine J774 and human alveolar macrophages (Effective conc. 100-200 μM). 10panx1 (100 μM) is shown to protect rat hippocampal neurons against death induction upon NMDAR overactivation by excitotoxic concentrations of NMDA (100 μM) in cultures and ameliorate withdrawal symptoms among morphine-treated rats in vivo (10 μg/rat via intrathecal injection). |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | film |
| color【颜色】 | white to beige |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
