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7β,25-dihydroxycholesterol
产品别名
64907-21-7
7β,25-dihydroxycholesterol
cholest-5-ene-3β,7β,25-triol
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H46O3 |
| Molecular weight | 418.65 |
| NACRES | NA.25 |
| General description【一般描述】 | 7β,25-dihydroxycholesterol (7β25OHC) is an isomer of 7α,25-dihydroxycholesterol (7α25OHC). Its synthesis from 7-keto,25-hydroxycholesterol (7k25OHC) is catalyzed by 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1). 11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2) catalyzes the reverse oxidation from 7β25OHC to 7k25OHC. |
| Application【应用】 | 7β,25-dihydroxycholesterol has been used as a substrate for 11β-Hydroxysteroid dehydrogenase (11β-HSD)-dependent metabolic studies of oxysterols in human embryonic kidney (HEK-293) cells in enzyme kinetics assay and as a standard in high-performance liquid chromatography(HPLC) for detection of dihydroxycholesterols in human plasma. |
| Biochem/physiol Actions【生化/生理作用】 | 7β,25-dihydroxycholesterol is an Epstein-Barr virus-induced gene 2 (EBI2) ligand and is comparatively a weaker chemoattractant than 7α,25-dihydroxycholesterol (7α25OHC). |
产品性质
| form【形式】 | powder |
| manufacturer/tradename | Avanti Polar Lipids 700081P |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | CC1(CC[C@H](O)C2)C2=C[C@H](O)C3C1CCC4(C)C3CCC4C(CCCC(C)(O)C)C |
| packaging【包装】 | 5 mL Amber Glass Screw Cap Vial (700081P-1mg) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
