广州伟伯科技有限公司
您的位置:首页 > 产品中心 > 1403-17-4, Candicidin
产品搜索:

Candicidin

产品编号:4066194
规格:≥50% (HPLC)
CAS NO:1403-17-4
包装规格:1 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40661941 MG1120
产品别名

1403-17-4

Candicidin

Candeptin

Candimon

Levorin

Vanobid

基本信息
Empirical Formula【经验(实验)分子式】
C59H84N2O18
Molecular weight
1109.30
General description【一般描述】
Candicidin is a polyene macrolide antifungal antibiotic which inhibits large number of fungi. 2 Polyene antifungal antibiotics, such as Candicidin, specifically target cell membranes containing sterols. Thus, selectively targets variety of prokaryotic organisms (such as Candida albicans) and not eukaryotic organisms. Candicidin generates cell membrane damage to Candida albicans (C.albicans) by triggering a rapid efflux of K+ ions. Interestingly, it was found that dosage needed for Candicidin to inhibit growth of stationary phase C. albicans cells is 25 μg/ml whereas log-phase C. albicans cells is only 5 μg/mL. In 1953 Kigman and Lewis performed the first in vivo study with mice to reveal the effects of Candicidin. Their study showed that Candicidin exhibits protective effect against C. albicans, Blastomyces dermatitidis and Sporotrichum schenkii but only a partial protective effect against torulosis and histoplasmosis. LD50 for Candicidin oral administration and intraperitoneal administration in mice were 90-400mg/kg and 2.1-7.0 mg/kg respectively. When comparing the activity of Candicidin to other antifungal compounds in vivo protects 100% of mice with C. albicans infection, whereas usage of twice the amount of Nystatin protects only 60% of the mice. Candicidin may undergo a photoisomerization process, yielding all-trans derivatives of Candicidin when exposed to direct UV light.
产品性质
biological source【生物来源】
Streptomyces griseus
Assay【测定】
≥50% (HPLC)
form【形式】
solid
storage condition【储存条件】
protect from light
solubility【溶解性】
DMSO: 1 mg/mL
storage temp.【储存温度】
−20℃
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
广州伟伯科技有限公司 版权所有 CopyRight ©2006-2024, All Rights Reserved
工信部备案号:粤ICP备08114744号   Page Run Time: 0.0082