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组蛋白 H2a 全长，人
Histone H2a full length human
| 产品编号： | 4067549 |
| 规格： | recombinant, expressed in E. coli, ≥90% (SDS-PAGE) |
| 包装规格： | 1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
组蛋白 H2a 全长，人
Histone H2a full length human
H2AFQ
histone cluster 2, H2ac
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | Histones make up the nucleosome, which is the fundamental unit of the chromatin. Each nucleosome consists of 146 base pairs of DNA which is wrapped around an octamer of four core histones H2A, H2B, H3 and H4. Histone cluster 2 H2A family member c (HIST2H2AC) has many variants. Human Histone 2A (GenBank Accession No. NM_033445) amino acids 2-130 (end) with N-terminal His-tag, MW = 14.8 kDa, expressed in an E. coli expression system. Histone cluster 2 H2A family member c (HIST2H2AC) is located on human chromosome 1q21. It is usually present in undifferentiated/proliferating cells. This canonical histone isoform has a protruding tail at both the N- and C-termini. |
| Biochem/physiol Actions【生化/生理作用】 | Histone cluster 2 H2A family member c (HIST2H2AC) has a role in maintaining the structure of the chromatin. Histone cluster 2 H2A family member c (HIST2H2AC) participates in multiple epigenetic regulations and carcinogenesis. It also participates in embryonic stem (ES) cell biology and regulates the expression of genes. It modulates proliferation and epithelial-mesenchymal transition in mammary epithelial and breast cancer cells. Hist2h2ac also controls epithelial differentiation. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥90% (SDS-PAGE) |
| form【形式】 | aqueous solution |
| mol wt【分子量】 | 14.8 kDa |
| packaging【包装】 | pkg of 1 mg |
| storage condition【储存条件】 | avoid repeated freeze/thaw cycles |
| concentration【浓度】 | 1.2 mg/mL |
| NCBI accession no.【NCBI登记号】 | NM_033445 |
| UniProt accession no.【UniProt登记号】 | Q16777 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... HIST2H2AC(8338) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
