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SIRT6抑制剂筛选试剂盒(荧光法)
SIRT6 Inhibitor Screening Kit (Fluorometric)
产品别名
SIRT6抑制剂筛选试剂盒(荧光法)
SIRT6 Inhibitor Screening Kit (Fluorometric)
产品性质
Quality Level【质量水平】 | 100 |
usage【用途】 | sufficient for 100 fluorometric tests |
Detection Method | fluorometric |
storage temp.【储存温度】 | −20℃ |
suitability【适用性】 | Suitable for screening, characterizing and studying SIRT6 inhibitors |
基本信息
General description【一般描述】 | SIRT6 or Sirtuin 6 proteins are a class of proteins that possess either histone deacetylase or mono-ribosyltransferase activity. SIRT6 is a nuclear sirtuin that has been associated with aging, cellular protection, sugar metabolism and certain types of cancer. Broad therapeutic applications are foreseen for SIRT6 inhibitors, including uses in diabetes, immune-mediated disorders, and cancer. Unlike other known protein deacetylases, which simply hydrolyze acetyl-lysine residues, the sirtuin-mediated deacetylation reaction hydrolyzes acetyl-lysine and NAD. This hydrolysis yields the deacetylated substrate, O-acetyl-ADP-ribose and nicotinamide, itself an inhibitor of sirtuin activity. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. |
Features and Benefits【特点和优势】 | Compatible with high-throughput handling systems. |
Principle【原理】 | In this Sirtuin 6 inhibitor screening kit, Sirtuin 6 deacetylates the substrate, followed by cleavage of the deacetylated substrate to release the fluorescent group, which is detected fluorometrically (λex = 400 nm/λem = 505 nm). |
安全信息
Pictograms【象形图】 | GHS05,GHS07,GHS08 |
Signal word【警示用语:】 | Danger |
Hazard Statements | H302 + H312 - H315 - H317 - H318 - H334 - H361d - H412 |
Precautionary Statements | P273 - P280 - P301 + P312 - P302 + P352 + P312 - P305 + P351 + P338 - P308 + P313 |
Hazard Classifications【危险分类】 | Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Repr. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 |
Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
WGK | WGK 3 |