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desmosterol-d6

产品编号:4071448
规格:cholesta-5,24-dien-3β-ol-d6, powder
CAS NO:1246298-67-8
包装规格:1 MG
产品类别:进口试剂
品牌:Avanti
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
40714481 MG4210
产品别名

1246298-67-8

desmosterol-d6

24-dehydrocholesterol(d6); 5,24-cholestadien-3β-ol(d6)

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C27H38OD6
Molecular weight
390.67
NACRES
NA.25
General description【一般描述】
Desmosterol constitutes 1% of brain sterol and is catabolized to cholesterol by the enzyme 3-hydroxysterol 24-reductase (DHCR24). It is an intermediate in the Bloch branch of the cholesterol biosynthesis pathway. Desmosterol-d6 is a deuterated form of desmosterol.
Application【应用】
Desmosterol-d6 has been used:
  • as a deuterated standard in liquid chromatography multiple reaction monitoring (LC-MRM)
  • as a deuterated standard in high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS)
  • for spiking brain tissue homogenate from Alzheimer′s disease (AD) for liquid chromatography -mass spectrometry (LC-MS) analysis

Biochem/physiol Actions【生化/生理作用】
Desmosterol low levels in the hippocampus directly impacts progenitor cell differentiation into neurons. Desmosterol-d6 is used as a substitute to desmosterol in hepatitis C virus (HCV) based viral assays to rescue replication. Desmosterol being a C27 sterol intermediate is implicated in the Alzheimer′s disease (AD) pathogenesis.
产品性质
Assay【测定】
>99% (TLC)
form【形式】
powder
manufacturer/tradename
Avanti Polar Lipids 700040P
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
packaging【包装】
5 mL Amber Glass Screw Cap Vial (700040P-1mg)
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
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