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p53Bridge ELISA

产品编号:4072823
包装规格:1 KIT
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
40728231 KIT14770
产品性质
Quality Level【质量水平】
100
antibody form【抗体形式】
purified antibody
species reactivity
human, mouse
shipped in【运输】
wet ice
storage temp.【储存温度】
2-8℃
基本信息
General description【一般描述】
A Protein Conformational Array (PCA) in a sandwich ELISA format where the plate is coated with a panel of 17 antibodies raised against peptides derived from the full length protein sequence of p53. Taken individually, each of these antibodies is strongly antigenic to the peptide sequence that was used in its production. However, when these peptides are incorporated into a full length correctly folded protein, the antigenicity of some of them is masked by the three dimensional structure of the protein and only a certain number of the antibodies respond. The result is a histogram which can be likened to a ‘fingerprint′ for correctly folded p53. For a testing sample from cancer tissue or cell line, if the protein is not mutated or the mutations do not impact the p53 HOS, the ‘fingerprint′ will match that of wild type p53. If the p53 mutations resulted in the alteration of the protein HOS, changes in the ‘fingerprint′ generated by the ELISA will point out differences between the mutant and wild type p53, this information may be valuable in the characterization of the p53 from cancer patient samples, cancer cell lines or other biological samples.
Application【应用】
For research use only. Not for use in diagnostic procedures.
Other Notes【其他说明】
ELISA kit contains three 96-well microplates and all the components necessary to complete an ELISA test.
安全信息
Pictograms【象形图】
GHS05
Signal word【警示用语:】
Warning
Hazard Statements
H290 - H315 - H319
Precautionary Statements
P234 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
Hazard Classifications【危险分类】
Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2
Storage Class Code【储存分类代码】
8B - Non-combustible, corrosive hazardous materials
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