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Pentabromopseudilin
产品别名
10245-81-5
Pentabromopseudilin
2,4-dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)phenol
PBP
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C10H4Br5NO |
| Molecular weight | 553.66 |
| General description【一般描述】 | Pentabromopseudilin (PBP) is a potent antibiotic originally isolated from the marine bacterium Pseudomonas bromoutilis. 2 PBP exhibits cytotoxic, antibacterial and phytotoxic activities, including the inhibition of human 12- and 15-lipoxygenases3 and potent inhibition of myosin-dependent processes. 4-5 PBP was identified as a potent inhibitor of the motor activity of vertebrate myosin V with an IC50 value of 1.2μM. 5 PBP inhibits the ATPase activity of myosin by increasing its affinity for ADP, reducing ATP-binding and hydrolysis rates, and through coupling between actin and nucleotide-binding sites in the motor domain. 4 Recently, it was also demonstrated that PBP suppresses TGF-β activity. |
| Other Notes【其他说明】 | Solubility: Chloroform/dichloromethane (at least 10 mg/ml), methanol/ethanol (at least 1 mg/ml), DMSO (10mM) Working Stock: PBP can be dissolved in DMSO at concentration of 10mM, solution should be stored in the dark at -80℃. |
产品性质
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | solid |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | OC1=C(Br)C=C(Br)C=C1C2=C(Br)C(Br)=C(Br)N2 |
| InChI | 1S/C10H4Br5NO/c11-3-1-4(9(17)5(12)2-3)8-6(13)7(14)10(15)16-8/h1-2,16-17H |
| InChI key | LXMNWKJHYOZUQL-UHFFFAOYSA-N |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
