Caspase-3 Inhibitor I-CAS 169332-60-9-Calbiochem

C₂₀H₃₀N₄O₁₁

502.47

MFCD00671412

A very potent, specific, and reversible inhibitor of caspase-3 (IC₅₀ = 200 pM), caspase-6, caspase-7, caspase-8, and caspase-10.
A specific and reversible inhibitor of CPP32/Apopain/Yama (IC₅₀ = 0.2 nM). A member of the ICE/CED-3 family of cysteine proteases, which are important in apoptosis.

Product does not compete with ATP.
Reversible: yes
Target IC₅₀: 200 pM against caspase-3
Cell permeable: no
Primary Target
Capase-3, capase-6, capase-7, capase-8, capase-10

Toxicity: Standard Handling (A)

Ac-Asp-Glu-Val-Asp-CHO

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature376, 37.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥90% (HPLC)

solid

Calbiochem^®

OK to freeze

white

DMSO: 5 mg/mL
water: soluble

ambient

−20℃

1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)/t11-,12-,13-,17-/m0/s1

UMBVAPCONCILTL-MRHIQRDNSA-N

1 mg in Glass bottle
5 mg in Plastic ampoule
Yes

11 - Combustible Solids

WGK 3