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产品别名
Reagent-cartridge CRBN-PEG3
Synple 2
产品性质
Quality Level【质量水平】 | 100 |
基本信息
General description【一般描述】 | Reagent-cartridge CRBN-PEG3 is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected aldehyde or ketone to the amine terminated linker through a reductive amination. This cartridge features a Cereblon (CRBN) recruiting ligand (pomalidomide) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. Scale: up to 0.1 mmol Linker: PEG3 E3 ligase target and ligand: Cereblon (CRBN), pomalidomide Terminal functional group: amine Compatible substrates: ketone, aldehyde Cartridge contents:
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Learn more about the Synple automated synthesis platform. Learn more about protein degradation. Explore all our Protein Degrader Building Blocks Features and Benefits of Synple Platform
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Other Notes【其他说明】 | An integrated console for capsule-based, automated organic synthesis |
Legal Information【法律信息】 | Product of Synple Chem AG PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
安全信息
Pictograms【象形图】 | GHS07 |
Signal word【警示用语:】 | Warning |
Hazard Statements | H315 - H319 |
Precautionary Statements | P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313 |
Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 |
Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
WGK | WGK 3 |