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22(R)-Hydroxycholesterol
| 产品编号： | 4075573 |
| 规格： | cholest-5-ene-3β,22(R)-diol, powder |
| CAS NO： | 17954-98-2 |
| 包装规格： | 1 MG，5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Avanti |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4075573 | 1 MG | 1380 | |||
| 4075573 | 5 MG | 4480 |
产品别名
17954-98-2
22(R)-Hydroxycholesterol
5-cholestene-3β,22-diol; 22-hydroxycholest-5-en-3-ol
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C27H46O2 |
| Molecular weight | 402.65 |
| General description【一般描述】 | 22(R)-hydroxycholesterol is a diastereomer of 22(S)-hydroxycholesterol. It is present in neonate brain. |
| Application【应用】 | 22(R)-hydroxycholesterol has been used as a liver X receptor (LXR) ligand in breast cancer cell lines. It may be used as an internal standard to spike mouse brain tissue samples for ultra-performance liquid chromatography–high resolution mass spectrometry (UPLC-ESI-HRMS) analysis. |
| Biochem/physiol Actions【生化/生理作用】 | 22(R)-hydroxycholesterol (22(R)-HC) is a liver X receptor (LXR) ligand.. 22(R)-HC in combination with other oxysterols promote mesenchymal stem cell osteogenesis. It regulates cholesterol homeostasis. Low levels of 22(R)-HC is observed in Alzheimer′s disease and it may be implicated in neuroinflammation and neurodegenerative diseases. 22(R)-hydroxycholesterol also suppresses prostate tumor progression. |
产品性质
| Assay【测定】 | >99% (TLC) |
| form【形式】 | powder |
| manufacturer/tradename | Avanti Polar Lipids 700058P |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C27H46O2/c1-17(2)6-11-25(29)18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20-,21-,22+,23-,24-,25+,26-,27+/m0/s1 |
| InChI key | RZPAXNJLEKLXNO-GFKLAVDKSA-N |
| packaging【包装】 | 5 mL Amber Glass Screw Cap Vial (700058P-5mg) 5 mL Amber Glass Screw Cap Vial (700058P-1mg) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
