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DyNAbind® 10 Million Compound DNA-Encoded Library
产品性质
| form【形式】 | pellets |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 |
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基本信息
| General description【一般描述】 |
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| Application【应用】 | This is a DNA-encoded library of 10 million small molecule compounds created by DyNAbind that can be used for drug discovery. Each compound is created using combinatorial chemistry to form trimers with over 200 building blocks at each of three positions. Each building block is tagged with a unique DNA barcode. When the building blocks are connected through amide bonds, the DNA is also combined forming a double-stranded DNA barcode for each compound. The compound is attached through an amide bond to a C6 linker which is then attached to an oxygen in the 5′ phosphate on the DNA. All the compounds fit in a single microcentrifuge tube. The compounds can be incubated with a target of interest that is attached to beads. After washing, the compounds bound to the target can be detected. The DNA barcodes are amplified using PCR and then detected using nextgen sequencing. The sequencing data can be loaded to a secure portal on our website for analysis. This will generate a report of the highest affinity compounds that were bound to the target. Several methods are used to QC the library. The initial single building blocks with their attached DNA barcodes are tested by LC-MS. PCR is used to monitor library assembly, and at completion the library is tested by nextgen sequencing to ensure reasonable compound distribution. The cost of the library includes generating a list of 50 hits or up to 60 hits if there are ties. All the hit structures will be revealed at no additional charge. There are also no additional licensing fees for using the compounds for research and development or manufacturing. This kit saves time since it can be bought and used without the negotiation required for licensing other DEL technologies. Analysis Portal More information about DyNAbind |
| Features and Benefits【特点和优势】 |
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| Legal Information【法律信息】 | Product of DyNAbind GmbH Label License: For R&D use only. Not for drug, household, or other uses. There are no restrictions, additional agreements, or fees required from Merck KGaA or from DyNAbind for using the identified compounds for any purpose. DyNAbind is a registered trademark of DyNAbind GmbH |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
