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(–)-PSI Reagent
产品别名
2245335-70-8
(–)-PSI Reagent
(–)-Ψ
(2S,3aS,6R,7aS)-3a-Methyl-2-((perfluorophenyl)thio)-6-(prop-1-en-2-yl)hexahydrobenzo[d][1,3,2]oxathiaphosphole 2-sulfide
Phosphorus-Sulfur Incorporation Reagent
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H16F5OPS3 |
| Molecular weight | 446.46 |
| Application【应用】 | Air- and moisture-tolerant, this (-)-PSI Reagent was developed in the Baran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (+)-PSI Reagent, is also available (cat# ALD00604). The PSI Reagents open access to thiophosphate-based nucleotide molecules with therapeutic promise as demonstrated by the Baran lab in the preparation of pure stereoisomers of cyclic dinucleotides (CDNs) and antisense oligonucleotides (ASOs). |
| Other Notes【其他说明】 | Unlocking P(V): Reagents for chiral phosphorothioate synthesis PSI on OpenFlask |
| Legal Information【法律信息】 | PCT/US2019/027256; U.S. Nonprovisional Patent Application #16/382,692 |
产品性质
| Assay【测定】 | 95% |
| form【形式】 | powder or crystals |
| mp | 103-107 ℃ |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
