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Anti-Calcineurin pan A Antibody
| 产品编号： | 4079366 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Calcineurin pan A Antibody
CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform, calcineurin A alpha, protein phosphatase 3 (formerly 2B), catalytic subunit,
alpha isoform, protein phosphatase 3 (formerly 2B), catalytic subunit,
alp
基本信息
| eCl@ss | 32160702 |
| General description【一般描述】 | Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin′s multifunctional capabilities in the regulation of calcium signaling. |
| Specificity【特异性】 | This antibody recognizes both the Aα and Aβ, the major catalytic subunit gene isoforms of calcineurin in most tissues; may also react with the testis form, Aγ. This antibody has very high sensitivity and specificity, which allow detection of calcineurin in tissues where expression is low, such as lymphoid tissue. Reacts with calcineurin of all mammalian species. |
| Immunogen【免疫原】 | KLH-conjugated synthetic peptide corresponding to Calcineurin. |
| Application【应用】 | Research Sub Category GPCR, cAMP/cGMP & Calcium Signaling Research Category Signaling Detect Calcineurin pan A using this Anti-Calcineurin pan A Antibody validated for use in WB. |
| Quality【质量】 | Evaluated by Western Blot in Mouse brain lysate. Western Blot Analysis: 1:1,000 dilution of this antibody detected Calcineurin on 10 µg of mouse brain lysate. |
| Linkage【联系】 | Replaces: AB1695 |
| Physical form【外形】 | Affinity purified Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative. |
| Analysis Note【分析说明】 | Control Mouse brain lysate |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse, human, rat |
| species reactivity (predicted by homology) | mammals (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_000935.1 |
| UniProt accession no.【UniProt登记号】 | Q08209 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~58 kDa |
| Storage and Stability【储存及稳定性】 | Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will remain unfrozen. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
