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Anti-ALKBH1 Antibody
| 产品编号： | 4079472 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-ALKBH1 Antibody
ALKBH1, Alkylated DNA repair protein alkB homolog 1, Alpha-ketoglutarate-dependent dioxygenase ABH1, DNA lyase ABH1, DNA oxidative demethylase ALKBH1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | ALKBH1 is a DNA lyase that is critical for DNA repair and specifically repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. ALKBH1 can also cleave both single-stranded and double-stranded DNA at basic sites, and ALKBH1 can induce double stranded breaks at basic sites. Finally, ALKBH1 plays a role in placental trophoblast lineage differentiation during development, and ALKBH1 may also play a role in neuronal development and migration. ALKBH1 is widely expressed and localizes to mitochondria and nucleus. The nuclear localization of ALKBH1 appears to be as part of fusion proteins with nuclear targeted proteins or when the first 26 N-terminal residues are removed. |
| Specificity【特异性】 | Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA (Westbye, M.P., et al. (2008). JBC. 283:25046-25056). |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the substrate binding region of human ALKBH1. Epitope: Around the Substrate binding region |
| Application【应用】 | Research Sub Category Nuclear Receptors Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected ALKBH1 in human pancreas and human kidney tissue. Anti-ALKBH1 Antibody is an antibody against ALKBH1 for use in Immunohistochemistry and Immunocytochemistry. Research Category Epigenetics & Nuclear Function |
| Quality【质量】 | Evaluated by Western Blotting in human skeletal muscle tissue lysate. Western Blotting Analysis: 0.1 µg/mL of this antibody detected ALKBH1 in 10 µg of human skeletal muscle tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse, human |
| species reactivity (predicted by homology) | rat (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_006011 |
| UniProt accession no.【UniProt登记号】 | Q13686 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~45 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
