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Anti-PDE4D3 Antibody
| 产品编号： | 4079562 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-PDE4D3 Antibody
cAMP-specific 3′,5′-cyclic phosphodiesterase 4D, DPDE3, PDE43
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Phosphodiesterase 4D3 (PDE4D3) is a member of the PDE cyclic nucleotides. PDE4D3 is known to be regulated by protein kinase C (PKC)-Raf-MEK-ERK and also by cAMP in vascular smooth muscle cells. PDE4D3 is a direct target of the MSH/cAMP/MITF pathway and may play a role in melanocyte differentiation. PDE4D3 is essential to have equilibrium in relaxing and contracting cues to airway smooth muscle. Down-regulation of PDE4D3 may be associated with analgesic and anti-inflammatory effects. PDE4D3 has also been linked to the risk of stroke, and in particular to polygenic stroke. |
| Specificity【特异性】 | This antibody recognizes PDE4D3 at the N-terminus. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the N-terminus of human PDE4D3. Epitope: N-terminus |
| Application【应用】 | Research Category Neuroscience Research Sub Category Developmental Neuroscience This Anti-PDE4D3 Antibody is validated for use in WB for the detection of PDE4D3. |
| Quality【质量】 | Evaluated by Western Blot in mouse brain membrane tissue lysate. Western Blot Analysis: 1 µg/mL of this antibody detected PDE4D3 on 10 µg of mouse brain membrane tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control Mouse brain membrane tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rhesus macaque, mouse, rat |
| species reactivity (predicted by homology) | rhesus monkey (based on 100% sequence homology), human (immunogen homology) |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_006194 |
| UniProt accession no.【UniProt登记号】 | Q08499 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... PDE4D(5144) |
产品说明
| Target description【目标描述】 | ~95 kDa observed. UniProt describes 12 isoforms produced by alternative splicing. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
