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达托霉素二甲基亚砜溶液
Daptomycin Ready Made Solution
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4079998 | 0.5 ML | 2180 |
产品别名
103060-53-3
达托霉素二甲基亚砜溶液
Daptomycin Ready Made Solution
N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine[egr]1-lactone
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C72H101N17O26 |
| Molecular weight | 1620.67 |
| MDL number | MFCD28968054 |
| Biochem/physiol Actions【生化/生理作用】 | Daptomycin is a natural cyclic lipopeptide antibiotic found in Streptomyces roseosporus. It is has been found to be effective in treating infections caused by aerobic Gram-positive bacteria. Daptomycin inhibits many antibiotic resistant strains such as methicillin-resistant S. aureus (MRSA), vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA). The mode of action of daptomycin is quite different from that of any other antibiotic. Daptomycin binds to bacterial membranes and causes a rapid depolarization of membrane potential. This loss of membrane potential causes inhibition of protein, DNA, and RNA synthesis, which results in bacterial cell death. |
| Preparation Note【制备说明】 | The 1 mg/mL solution may be further diluted in an appropriate buffer prior to use. It is recommended that a fresh dilution be made on the day of use. |
| Other Notes【其他说明】 | Keep container tightly closed in a dry and well-ventilated place. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | Streptomyces roseosporus |
| description【描述】 | Ready Made Solution |
| form【形式】 | liquid |
| storage condition【储存条件】 | (Keep container tightly closed in a dry and well-ventilated place.) |
| concentration【浓度】 | 1 mg/mL in DMSO |
| color【颜色】 | colorless to faint yellow |
| Mode of action【作用机制】 | DNA synthesis | interferes protein synthesis | interferes |
| antibiotic activity spectrum【抗生素抗菌谱】 | Gram-positive bacteria |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | O=C(NCC(N[C@H](CCCN)C(N[C@@H](CC(O)=O)C(N[C@H](C)C(N[C@@H](CC(O)=O)C(NC1)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CC(O)=O)NC([C@@H](CC(N)=O)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CCCCCCCCC)=O)=O)=O)=O)[C@@H](C)OC([C@H](CC(C4=C(N)C=CC=C4)=O)NC([C@@]([C@H](C)CC(O)=O)([H])NC( |
| InChI | 1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35?,36-,37?,43+,44+,45+,46+,47+,48+,49+,50-,60+,61?/m1/s1 |
| InChI key | DOAKLVKFURWEDJ-OFNKPWESSA-N |
| packaging【包装】 | 0.5ML |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Flash Point(F)【闪点(F)】 | 188.6 °F |
| Flash Point(C)【闪点(C)】 | 87 ℃ |
