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产品别名
InSolution PI-103
mTOR Inhibitor V, PI 3-K Inhibitor V
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H16N4O3 |
| Molecular weight | 348.36 |
| General description【一般描述】 | A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC50 = 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110δ, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively). It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 µM. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo. |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 10 mM (2 mg/574 µl) solution of PI-103 (Cat. No. 528100) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-20°C). |
| Other Notes【其他说明】 | Raynaud, F.I., et al. 2007. Cancer Res.67, 5840. Fan, Q.W., et al. 2006. Cancer Cell9, 341. Knight, Z.A., et al. 2006. Cell125, 733. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 2 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
| Flash Point(F)【闪点(F)】 | 188.6 °F - (Dimethylsulfoxide) |
| Flash Point(C)【闪点(C)】 | 87 ℃ - (Dimethylsulfoxide) |
